A pair of any 5x0's will always be faster than a single 6x0 (of the same x number), but the gain in Vram won't compensate performance. Only get it if you intend on a second one at some point.
Vram itself is largely a consideration for future-proofing, apart from present-day multi-display setups, future games will push the Vram usage even at your same resolutions, it is not like there is a maximum for a resolution to the point where you choose one versus the other where it is obvious, I'm starting to think that is BS.
ManBearPig
VRAM hasn't been an issue at 1080p, but I'm not sure if 1.25GBs is enough for 1440p.
You're getting stuck on the wrong concept, per se, Vram usage has more to do with which game and detail level you choose, rather than resolution alone.
For example, when Dell debuted the their 2560x1600 30" display back in winter of 2005, those high-end gamer cards (GeForce 7800GTX and Radeon X1800) didn't have more than 512MB per GPU. We're they struggling? Only in the sense that the games of the day at high-details tended to reach about 40FPS with a single-GPU, but a second card would fix that, meaning those games of the day weren't pushing more than 512MB even at 2560x1600 to be a problem. Fast-forward to today and depending on our preferences, some people are good with 2GB while others need more
at the same resolution. That is why I'm saying this is about your games, next year there will be a title that pushes average Vram above 2GB even at 1080p, it will happen.
We can also say our hardware adjusts to our games, that if you have more Vram, the game will use more; that doesn't mean it was supposed to as a requirement. Not until I got a GTX260 did the first Crysis at 1080p use 802 out of 896MB, but it was fine in the 512MB of a 9800GT and the performance difference happened to match the ratio of CUDA cores, about 65% better at the same settings. So where did the extra 300MB of Vram usage come from? The game adjusted to my hardware, simple as that. Many games that first appeared in 2007, the hardware wasn't available to push the VRam I eventually saw with my GTX260, like HL2:Ep2 saw 610MB at 1080p max detail which was higher than most 8-series and 9-series cards at the time (except for G80 based cards). Crysis first appeated in Oct 2007 while 768MB per GPU was max in 8800GTX cards. But I saw it use 802MB in my GTX260 years later.
It is not a descrepency, it is adjustment. Likewise for any resolution, your game will adjust to more Vram or less, it is not like you're being held back, per se. That said, like I said up top, get more Vram for the sole purpose of future games provided you intend to get new games later. That might sound strange, but people upgrade their hardware based on the idea that time stops right here (i.e. not using more now = always be the case, so no need to get more), so unless they also plan to stop getting games, they can't use that ideology. People use that logic mostly with PCIe lane specifications, that beacuse they won't need it now, they don't plan ahead.